Het Buitengasthuis speelde een belangrijke rol in de laatste pokkenepidemie van 1870-1872. Geneesheer Guillaume Daniel Louis Huet reflecteerde op het verloop van de epidemie in het Buitengasthuis. De cijfers bleken er niet om te liegen: meer dan twee-derde van de 1441 mensen die ten tijde van epidemie in het Buitengasthuis waren verpleegd was weliswaar ooit gevaccineerd, maar niet gehervaccineerd…
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